Product Description: BMY 28674 (6-Hydroxybuspirone) is the active metabolite of the anxiolytic buspirone (HY-B1115A) and is metabolized by CYP3A4.4. BMY 28674 binds to the serotonin (5-HT) receptor subtype 5-HT1A in the rat hippocampus and dorsal raphe (EC50s are 4 and 1 μM, respectively) and is an antagonist of dopamine D2, D3, and D4 receptors (IC50s are 3.1, 4.9, and 0.85 μM, respectively). BMY 28674 also inhibits organic cation transporter 1 (OCT1), OCT2, and OCT3 expressing human transporters in S2 proximal tubule cells in a concentration-dependent manner.
Applications: Neuroscience-Neuromodulation
Formula: C21H31N5O3
References: [1]Zhu, et al. Cytochrome P450 3A-mediated metabolism of buspirone in human liver microsomes. Drug Metab. Dispos. 33(4), 500-507 (2005).
CAS Number: 125481-61-0
Molecular Weight: 401.50
Research Area: Neurological Disease
Target: 5-HT Receptor;Dopamine Receptor;Drug Metabolite
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