Clone Name: 9E10
Light Chain: Kappa
Application Note: IHC-P: 1:50-1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Form: Liquid
Buffer (with preservative): batch dependent
Concentration: Batch dependent (Please refer to the vial label for the specific concentration.)
Background: This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini. [provided by RefSeq, Aug 2017]
Uniprot ID: P01106
Antigen Species: Human
Immunogen: A synthetic peptide, corresponding to aa 408-439 (AEEQKLISEEDLLRKRREQLKHKLE QLRNSCA) from C-terminus of human c-myc, coupled to KLH 9.
Purification: Unpurified
Conjugation: Unconjugated
Full Name: MYC proto-oncogene, bHLH transcription factor
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