Description of Target: Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts. (Microbial infection) Acts as a receptor for human immunodeficiency virus-1.
Key Reference: The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family. Maddon P.J., Littman D.R., Godfrey M., Maddon D.E., Chess L., Axel R. Cell 42:93-104(1985).
Molecular Weight: 45.3 kDa.
Product Format: Liquid or Lyophilized powder.
Protein Name: T-cell surface glycoprotein CD4.
Protein Sequence: KKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICEVEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASSIVYKKEGEQVEFSFPLAFTVEKLTGSGELWWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQALPQYAGSGNLTLALEAKTGKLHQEVNLVVMRATQLQKNLTCEVWGPTSPKLMLSLKLENKEAKVSKREKAVWVLNPEAGMWQCLLSDSGQVLLESNIKVLPTWSTPVQP.
Protein Size: 26–396 aa.
Purity: Greater than 90% as determined by SDS-PAGE.
Source: in vitro E. Coli expression system.
Tag: N-terminal 6xHis-tagged