Target Synonym: HLA class II histocompatibility antigen gamma chain;HLADG;Ia antigen-associated invariant chain;Ia-GAMMA II;Ii;p33;CD74 HLA-DR antigens-associated invariant chain;DHLAG;CD74;invariant chain;CD 74;CD74 antigen;CD74 antigen (invariant polypeptide of major histocompatibility complex;CD74 molecule;class II antigen-associated);class II invariant chain;CLIP;Gamma chain of class II antigens;HG2A;HLA DR antigens associated invariant chain;HLA DR gamma;HLADR antigens associated invariant chain;HLA-DR antigens-associated invariant chain;HLA-DR-gamma;Ia antigen associated invariant chain;Ia associated invariant chain;Ia gamma;Ia-GAMMA;Invariant polypeptide of major histocompatibility complex class II antigen associated;la-gamma;major histocompatibility complex;Major histocompatibility complex class II invariant chain;MHC HLA DR gamma chain;MHC HLA-DR gamma chain;p35;Protein 41;CD74;DHLAG;HLA class II histocompatibility antigen gamma chain;HLADG;Ia antigen-associated invariant chain;p33;CD 14;CD_antigen=CD14;CD14;CD14 antigen;CD14 molecule;LPS-R;Mo2;Monocyte differentiation antigen CD14;Monocyte differentiation antigen CD14 urinary form;membrane-bound form;Myeloid cell specific leucine rich glycoprotein;Myeloid cell-specific leucine-rich glycoprotein
Background: CD74 is a type II transmembrane glycoprotein also known as MHC class II associated invariant chain, invariant chain, Ii, MHC class II chaperone, and MIF receptor. CD74 exists in four isoforms with molecular masses of 33, 35, 41, and 43 kD, depending on genetic splicing. CD74 is primarily expressed on antigen presenting cells, including B cells, monocytes/macrophages, dendritic cells, and Langerhans cells. It is also expressed by activated T cells and activated endothelial and epithelial cells as well as carcinomas of lung, renal, gastric and thymic origin. The primary function of CD74 is intracellular sorting of MHC class II molecules and regulation of exogenous peptide loading onto MHC class II. It is also involved in the modulation of B cell differentiation and positive selection of CD4+ T cells. It has been reported that CD74 binds MIF (macrophage migration inhibitory factor) and signals through CD44 to regulate innate and adaptive immunity. It is also reported that H. pylori infection occurs through urease B binding of CD74 on gastric epithelial cells, inducing gastric epithelial cell apoptosis, NF-κB activation, and IL-8 production.
Immunogen: Recombinant Human CD74 protein
Buffer: 0.2 μm filtered solution in PBS
Dilution: IHC-P 1:500-1:2000;FCM 1:25-1:100;
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