CHS-828 (Standard), CAS 200484-11-3

Product Description: CHS-828 (Standard) is the analytical standard of CHS-828. This product is intended for research and analytical applications. CHS-828 (GMX1778) is a competitive inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), with an IC50 less than 25 nM. CHS-828 (GMX1778) exerts a cytotoxic effect by decreasing the cellular level of NAD+ and exhibits a potent anticancer activity[1].

Formula: C19H22ClN5O

References: [1]Watson M, et al. The small molecule GMX1778 is a potent inhibitor of NAD+ biosynthesis: strategy for enhanced therapy in nicotinic acid phosphoribosyltransferase 1-deficient tumors. Mol Cell Biol. 2009 Nov;29(21):5872-88./[2]Cerna D, et al. Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) activity by small molecule GMX1778 regulates reactive oxygen species (ROS)-mediated cytotoxicity in a p53- and nicotinic acid phosphoribosyltransferase1 (NAPRT1)-dependent manner. J Biol Chem. 2012 Jun 22;287(26):22408-17.

CAS Number: 200484-11-3

Molecular Weight: 371.86

Research Area: Cancer

Target: Apoptosis;NAMPT;Reference Standards

• Artikelnummer: MEXHY-10079R-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-10079R-0
• Verpackungseinheit: Get quote
• Mengeneinheit: STK