Shelf life (days): 1460
Info: A LRRK2 inhibitor (IC50 = 15 nM); selective for LRRK2 over a panel of 44 other kinases but does inhibit MAPK4 and Pim-2 at 1 µM; inhibits FLT3 at 10 µM; decreases the production of Aβ42 in a reporter assay using H4 cells overexpressing Aβ42 (IC50 = 15 µM); inhibits EGF-induced activation of MAPK in serum-starved cells at 20 µM; increases the survival of primary rat granule neurons in low potassium media at 1, 5, or 25 µM
Formulation: A solid
Formal Name: 5-chloro-3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-1,3-dihydro-2H-indol-2-one
Purity: ≥95%
Formula Markup: C15H8Br2ClNO2
Formula Weight: 429.49026
CAS Number: 220904-99-4