Clasto-Lactacystin β-lactone, CAS 154226-60-5

Formulation: A solution in methyl acetate

Formal Name: 1R-[1S-1hydroxy-2-methylpropyl]-4R-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione

Purity: ≥95%

Formula Markup: C10H15NO4

Formula Weight: 213,2

Shelf life (days): 730

CAS Number: 154226-60-5

Notes: Lactacystin is a microbial metabolite isolated from Streptomyces that is now widely used as a selective inhibitor of the 20S proteasome.{10086,2351,10073} Clasto-lactacystin β-lactone was later identified as the active metabolite of lactacystin, resulting from the elimination of cysteine and the formation of a reactive β-lactone. Both lactacystin and its β-lactone metabolite induce differentiation and inhibit cell cycle progression in several tumor cell lines.{1659} Clasto-lactacystin β-lactone irreversibly alkylates subunit X of the 20S proteasome.{10073} It is at least 10 times more active than the parent compound; this increased activity may be a function of increased cell permeability. Inhibition of proteasome peptidase activity results in the accumulation of a variety of ubiquitinated proteins which would normally undergo rapid degradation. Thus, the effects of clasto-lactacystin β-lactone are pleiotropic and depend substantially on the expression pattern of signaling proteins within the treated cell.

• Artikelnummer: CAY70988-100
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 70988-100
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK