Target Synonym: CLPS;colipase;COL;Colipase pancreatic;Pancreatic colipase preproprotein
Background: The protein encoded by this gene is a cofactor needed by pancreatic lipase for efficient dietary lipid hydrolysis. It binds to the C-terminal, non-catalytic domain of lipase, thereby stabilizing an active conformation and considerably increasing the overall hydrophobic binding site. The gene product allows lipase to anchor noncovalently to the surface of lipid micelles, counteracting the destabilizing influence of intestinal bile salts. This cofactor is only expressed in pancreatic acinar cells, suggesting regulation of expression by tissue-specific elements. Three transcript variants encoding different isoforms have been found for this gene.
Immunogen: Recombinant Human CLPS Protein
Buffer: 0.2 μm filtered solution in PBS
Dilution: IHC-P 1:100-1:500;
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