Target Synonym: KUB;AAG;Ku70-binding protein;Sulfated glycoprotein;Complement-associated protein SP;Testosterone-repressed prostate message;NA1/NA;SGP;CLU;AAG4;APO-J;APOJ;CLI;CLU1;CLU2;KUB1;NA1/NA2;SGP-2;SGP2;SP-40;TRPM-2;TRPM2;clusterin;CLUS;Aging-associated gene 4 protein;Apolipoprotein J;Complement cytolysis inhibitor;Complement-associated protein SP-40;Ku70-binding protein 1;Sulfated glycoprotein2;Testosterone-repressed prostate message 2;Complement cytolysis inhibitor a chain;Clusterin alpha chain;Complement cytolysis inhibitor b chain;APOJ CLI;Sulfated glycoprotein 2
Background: Clusterin, also known as complement-associated protein SP-40, Complement cytolysis inhibitor, Apolipoprotein J, Testosterone-repressed prostate message 2, Aging-associated gene 4 protein, CLU and APOJ, is a secreted protein which belongs to the clusterin family. Clusterin/Apolipoprotein J/Apo-J is an enigmatic glycoprotein with a nearly ubiquitous tissue distribution and an apparent involvement in biological processes ranging from mammary gland involution to neurodegeneration in Alzheimer's disease. Its major form, a heterodimer, is secreted and present in physiological fluids, but truncated forms targeted to the nucleus have also been identified. Clusterin/Apolipoprotein J/Apo-J is a widely distributed glycoprotein with a wide range of biologic properties. A prominent and defining feature of clusterin is its marked induction in such disease states as glomerulonephritis, cystic renal disease, renal tubular injury, neurodegenerative conditions, atherosclerosis, and myocardial infarction. Upregulation of clusterin mRNA and protein levels detected in diverse disease states and in in vitro systems have led to suggestions that it functions in membrane lipid recycling, in apoptotic cell death, and as a stress-induced secreted chaperone protein, amongst others.
Immunogen: Recombinant Human Clusterin / Apolipoprotein J / Apo-J Protein
Buffer: 0.2 μm filtered solution in PBS
Dilution: WB 1:500-1:1000;FCM 1:100-1:500;ICC/IF 1:100-1:500;
Calculated MW: 52 kDa
Observed MW: 57 kDa
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