Product Description: CP-724714 is a potent, selective and orally active ErbB2 (HER2) tyrosine kinase inhibitor, with an IC50 of 10 nM. CP-724714 displays a marked selectivity against EGFR kinase (IC50=6400 nM). CP-724714 potently inhibits ErbB2 receptor autophosphorylation in intact cells. Antitumor activities[1][2].
Applications: Cancer-Kinase/protease
Formula: C27H27N5O3
References: [1]Jani JP, et al. Discovery and pharmacologic characterization of CP-724,714, a selective ErbB2 tyrosine kinase inhibitor. Cancer Res, 2007, 67(20), 9887-9893./[2]Feng B, et al. Role of hepatic transporters in the disposition and hepatotoxicity of a HER2 tyrosine kinase inhibitor CP-724,714. Toxicol Sci, 2009, 108(2), 492-500.
CAS Number: 383432-38-0
Molecular Weight: 469.55
Compound Purity: 98.72
Research Area: Cancer
Solubility: DMSO : ≥ 50 mg/mL
Target: Apoptosis;EGFR
Deutsch
English
