Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 8-[(3,5-dimethyl-1H-pyrazol-4-yl)oxy]-5,7-dihydroxy-2-[4-[4-(2-pyridinyl)-1-piperazinyl]phenyl]-4H-1-benzopyran-4-one
Purity: ≥95%
Formula Markup: C29H27N5O5
Formula Weight: 525.6
CAS Number: 2410534-62-0
Notes: A USP8 inhibitor (IC50 = 1.2 µM); selective for USP8 over USP2 and USP7 (IC50s = 58.4 and >100 µM, respectively); induces apoptosis in, and inhibits colony formation by, MCF-7 cells from 1-5 µM; reduces tumor volume in an MCF-7 mouse xenograft model at 20 mg/kg