eIF2α Activator 2, CAS 1501618-04-7

Formulation: A solid

Formal Name: N-[trans-4-[4-(trifluoromethyl)phenoxy]cyclohexyl]-N′-[3-(trifluoromethyl)phenyl]-urea

Purity: ≥98%

Formula Markup: C21H20F6N2O2

Formula Weight: 446,4

Shelf life (days): 1460

CAS Number: 1501618-04-7

Notes: eIF2α activator 2 is an activator of eukaryotic translation initiation factor 2α kinase 1 (EIF2AK1), also known as heme-regulated inhibitor kinase (HRI).{68608} It activates HRI and induces eIF2α phosphorylation in a surrogate cell-based reporter assay. eIF2α activator 2 selectively inhibits the proliferation of CRL-2813 melanoma cells (IC50 = 0.46 µM) over non-cancerous NIH3T3 fibroblasts (IC50 = 3.4 µM). It also selectively inhibits the proliferation of CRL-2813 cells transiently transfected with non-targeted siRNA (IC50 = 0.66 µM) over those transiently transfected with HRI-targeted siRNA (IC50 = 5 µM). eIF2α activator 2 (5 µM) increases mRNA expression and protein levels of the eIF2α target DNA damage-inducible transcript 3 (DDIT3), also known as C/EBP homologous protein (CHOP), in CRL-2813 cells.{68609}

• Artikelnummer: CAY40130-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 40130-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK