Product Type: Antagonist
CAS No.: 945714-67-0
MolecularFormula: C20H22ClNO
Molecular Weight: 327,1
Source: Synthetic
Purity: >98% (TLC); NMR (Conforms)
Solubility: May be dissolved in DMSO (30 mg/ml); or Ethanol (25 mg/ml)
Appearance: White powder
PubChem CID: 24752728
Scientific Background: A high-affinity RAGE (Receptor for Advanced Glycation End products) receptor antagonist (Ki = 25 nM). It lowers levels of Aβ via binding to the V domain of RAGE and can block multiple mechanisms of Aβ40- and Aβ42-induced cellular stress in RAGE-expressing brain endothelium, neurons and microglia in vitro and in vivo (1,2). In a rat model of intracerebral hemorrhage, FPS-ZM1 attenuates blood-brain barrier and white matter fiber damage (3). It ameliorates inflammatory damage after acute intracerebral hemorrhage via downstream blockade of high mobility box-1(HMGB1) signaling (4). Attenuates AGE-induced neuroinflammation and oxidative stress in rat microglia (5). BBB permeable.
References: 1.R Deane et al. J. Clin. Invest. 2012 122:13772.Y Hong et al. Neurochem. Res. 2016 41:11923.F Yang et al. Stroke 2015 46:13284.D Li et al. Neurosci. Lett. 2015 609:1095.C Shen et al. Neurochem. Res. 2017 June 29 epub
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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