Target: GABA A Receptor
Conjugate: HRP
Product Type: Monoclonal
Clone Number: N398A/34 (Formerly sold as S398A-34)
Immunogen: Fusion protein amino acids 410-450 (Cytoplasmic C-terminus) of rat GABA-A-Receptor Alpha 4
Swiss-Prot: P28471
Purification: Protein G Purified
Storage Buffer: 73.64mM Carbonate, 54.55mM Ethanolamine, 45.45mM Cyanoborohydride, 18.18mM Sodium Hydroxide and 0.23mM Citrate in dH2O
Concentration: 1 mg/ml
Specificity: Detects ~60kDa. Does not cross-react with other GABA-A-Receptor Alpha subunits.
Cellular Localization: Cell Junction / Synapse / Postsynaptic Cell Membrane / Cell Membrane
Scientific Background: The GABA-A receptor is a member of the superfamily of fast acting ligand-gated ion channels. The individual subunits of these receptors have similar sequences and structural features (1). GABA-A receptors are the major fast inhibitory neurotransmitter gated ion channels in the brain (2). GABA-A Receptor Alpha 4 is associated with epilepsy (3), and research suggests that alterations in GABA- A Receptors subtypes may be involved in the resistance to antiepileptic drugs (4).
References: 1. Bracamontes J.R. and Steinbach J.H. (2008) J Bio Chem. 283: 26128-26136.2. Macdonald R.L., Olsen R.W. (1993) Annu Rev Neurosci. 17: 569-602.3. Grabenstatter H.L., et al. (2014) Epilepsia. 55(11): 1826-1833.4. Bethmann K., Fritschy J.M., Brandt C., Loscher W. (2008) Neurbiol Dis. 31(2): 169-187.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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