Target: NMDAR2A NMDA
Conjugate: HRP
Product Type: Monoclonal
Clone Number: N327/95 (Formerly sold as S327-95)
Immunogen: Fusion protein amino acids 75-325 (extracellular N-terminus) of rat GluN2A/NR2A
Swiss-Prot: Q00959
Purification: Protein G Purified
Storage Buffer: 73.64mM Carbonate, 54.55mM Ethanolamine, 45.45mM Cyanoborohydride, 18.18mM Sodium Hydroxide and 0.23mM Citrate in dH2O
Concentration: 1 mg/ml
Specificity: Detects ~170kDa. Does not react with NR2B.
Cellular Localization: Cell Membrane / Cell Junction
Scientific Background: N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate-gated ion channels. These receptors have been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C) and NMDAR2D (GRIN2D).
References: 1. Teng H.J., et al. (2010) PLoS ONE. 5: e13342.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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