Shelf life (days): 1460.0
Formulation: A solid
Formal Name: aR-[[6-(4-amino-1-piperidinyl)-3,5-dicyano-4-ethyl-2-pyridinyl]thio]-benzeneacetamide
Purity: ≥98%
Formula Markup: C22H24N6OS / HCl
Formula Weight: 420.535
CAS Number: 2170140-50-6
Notes: A DMNT1 inhibitor (IC50 = 0.23 µM); selective for DMNT1 over DMNT3A/3L and DMNT3B/3L and a panel of 34 methyltransferases and 369 kinases (IC50s = >10 µM for all); inhibits the proliferation of 51 hematological cancer cell lines (median IC50 = 0.64 µM); decreases overall DNA methylation and gene expression in MV4-11, THP-1, and NOMO-1 cells in a time- and concentration-dependent manner; increases the expression of genes encoding CXCL11, IFI27, and MAGEA4; reduces tumor volume and increases survival but does decrease blood numbers of neutrophils and red blood cells in SKM-1 and MV4-11 leukemia mouse xenograft models at 45, 30, or 15 mg/kg twice per day
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