Product Description: H2L5186303 is a potent and selective LPA2 receptor antagonist with an IC50 of 9 nM. H2L5186303 promotes Apoptosis. H2L5186303 inhibits cell proliferation and motility. H2L5186303 has anti-inflammatory effects[1][2][3].
Applications: Neuroscience-Neuromodulation
Formula: C26H20N2O8
References: [1]Fells JI, et al. Structure-based drug design identifies novel LPA3 antagonists. Bioorg Med Chem. 2009 Nov 1;17(21):7457-64./[2]Ye-Ji Lee, et al. Efficacy Comparison of LPA2 Antagonist H2L5186303 and Agonist GRI977143 on Ovalbumin-Induced Allergic Asthma in BALB/c Mice. Int J Mol Sci. 2022 Aug 28;23(17):9745./[3]Zhongxing Liang, et al. Compensatory Upregulation of LPA2 and Activation of the PI3K-Akt Pathway Prevent LPA5-Dependent Loss of Intestinal Epithelial Cells in Intestinal Organoids. Cells. 2022 Jul 20;11(14):2243./[4]Ishimoto K, et al. Rapid establishment of highly migratory cells from cancer cells for investigating cellular functions. J Recept Signal Transduct Res. 2019 Jun;39(3):194-198.
CAS Number: 139262-76-3
Molecular Weight: 488.45
Compound Purity: 98.72
Research Area: Inflammation/Immunology
Solubility: DMSO : 250 mg/mL (ultrasonic)
Target: Apoptosis;LPL Receptor
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