Application Note: WB: 0.1-0.3μg/ml. IHC-P: 3.75μg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 76
Positive Control: The peptide used to generate this antibody is available for purchase (GTX89202-PEP).
Specificity/Sensitivity: This antibody is expected to recognize all reported isoforms (NP_003940.1, NP_817084.1)
Form: Liquid
Buffer (with preservative): TBS, 0.5% BSA, 0.02% Sodium azide.
Concentration: 0.50 mg/ml (Please refer to the vial label for the specific concentration.)
Background: Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Uniprot ID: P54257
Antigen Species: Human
Immunogen: Peptide with sequence C-RYDFRYSEDREQ, from the internal region of the protein sequence according to NP_003940.2; NP_817084.1.
Purification: Purified by ammonium sulphate precipitation followed by antigen affinity chromatography
Conjugation: Unconjugated
Full Name: huntingtin associated protein 1
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