Her2 / ErbB2 antibody (CB11)

Her2 / ErbB2 antibody (CB11)
Artikelnummer
GTX75559-500
Verpackungseinheit
500 μl
Hersteller
GeneTex

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Clone Name: CB11

Application Note: IHC-P: 1:40. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Calculated MW: 138

Specificity/Sensitivity: This antibody recognizes human c-erbB-2 oncoprotein (internal domain).

Form: Liquid

Buffer (with preservative): Tissue culture supernatant, 0.09% Sodium azide.

Concentration: >26 μg/ml (Please refer to the vial label for the specific concentration.)

Background: This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]

Uniprot ID: P04626

Antigen Species: Human

Immunogen: Synthetic peptide corresponding to a site on the internal domain of the human c-erbB-2 oncoprotein .

Purification: Unpurified

Conjugation: Unconjugated

Full Name: erb-b2 receptor tyrosine kinase 2
Mehr Informationen
Artikelnummer GTX75559-500
Hersteller GeneTex
Hersteller Artikelnummer GTX75559-500
Verpackungseinheit 500 μl
Mengeneinheit STK
Reaktivität Human
Klonalität Monoclonal
Methode Immunohistochemistry (paraffin)
Isotyp IgG1
Human Gene ID 2064
Wirt Mouse
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