Background: This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]
Description: Recombinant human CDH17 protein with C-terminal 6×His tag
Molecular Weight: The protein has a predicted molecular mass of 85.7 kDa after removal of the signal peptide. The apparent molecular mass of CDH17-His is approximately 100-130 kDa due to glycosylation.
Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Tag: C-6×His Tag
Expression Host: HEK293
Formulation & Reconstitution: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Target: CDH17
Uniprot ID: Q12864
Usage: Research use only
Molecular Characterization: CDH17(Gln23-Met787) 6×His tag
Purity: The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining.
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