Background: This gene encodes a member of the desmoglein family and cadherin cell adhesion molecule superfamily of proteins. Desmogleins are calcium-binding transmembrane glycoprotein components of desmosomes, cell-cell junctions between epithelial, myocardial, and other cell types. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This gene is present in a gene cluster with other desmoglein gene family members on chromosome 18. Mutations in this gene have been associated with arrhythmogenic right ventricular dysplasia, familial, 10. [provided by RefSeq, Jan 2016]
Description: Recombinant Human DSG2(24-609) Protein with C-terminal 6×His tag
Molecular Weight: The protein has a predicted molecular mass of 66.4 kDa after removal of the signal peptide. The apparent molecular mass of DSG2(24-609)-His is approximately 70-100 kDa due to glycosylation.
Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Tag: C-6×His Tag
Expression Host: HEK293
Formulation & Reconstitution: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Target: DSG2
Uniprot ID: Q14126
Usage: Research use only
Molecular Characterization: DSG2(Leu24-Gly609) 6×His tag
Purity: The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining.
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