Background: This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Description: Human EDNRA-Strep full length protein-synthetic nanodisc
Molecular Weight: The human full length EDNRA-Strep protein has a MW of 48.7 kDa
Protein Families: GPCR,Transmembrane,Druggable Genome,
Protein Pathways: GPCRDB Class A Rhodopsin-like,GPCRDB Other,Peptide GPCRs,Prostaglandin synthesis regulation,Angiogenesis,Cancer,Endothelial Cell Biology,
Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Tag: C-Flag&Strep Tag
Expression Host: HEK293
Formulation & Reconstitution: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments.
Target: EDNRA
Uniprot ID: P25101
Usage: Research use only
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