Human EGFRVIII Protein, His Tag

Background: The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer.

Description: Recombinant Human EGFRVIII Protein with C-terminal 6×His tag

Molecular Weight: The protein has a predicted molecular mass of 39.5 kDa after removal of the signal peptide. The apparent molecular mass of EGFRVIII-His is approximately 55-100 kDa due to glycosylation.

Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Tag: C-6×His Tag

Expression Host: HEK293

Formulation & Reconstitution: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.

Target: EGFRVIII

Uniprot ID: P00533

Usage: Research use only

Molecular Characterization: EGFRVIII(Leu25-Ser645 △267aa) 6×His tag

Purity: The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining.

• Artikelnummer: DMAPME101321-50
• Hersteller: DIMA Biotechnology
• Hersteller Artikelnummer: PME101321-50
• Verpackungseinheit: 50 µg
• Mengeneinheit: STK
• Konjugat: Unconjugated