Background: This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases.
Description: Recombinant human PD-1 protein with C-terminal 6×His tag
Molecular Weight: The protein has a predicted molecular mass of 16.8 kDa after removal of the signal peptide.
Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Tag: C-6×His Tag
Expression Host: HEK293
Formulation & Reconstitution: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Target: PD-1
Uniprot ID: Q15116
Usage: Research use only
Molecular Characterization: PD-1(Leu25-Gln167) 6×His tag
Purity: The purity of the protein is greater than 90% as determined by SDS-PAGE and Coomassie blue staining.
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