Background: This gene represents a phospholipase A2 receptor. The encoded protein likely exists as both a transmembrane form and a soluble form. The transmembrane receptor may play a role in clearance of phospholipase A2, thereby inhibiting its action. Polymorphisms at this locus have been associated with susceptibility to idiopathic membranous nephropathy. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010]
Description: Recombinant Human PLA2R1(21-164) Protein with C-terminal human Fc tag
Molecular Weight: The protein has a predicted molecular mass of 42.2 kDa after removal of the signal peptide. The apparent molecular mass of PLA2R1(21-164)-hFc is approximately 35-55 kDa due to glycosylation.
Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Tag: C-Human Fc Tag
Expression Host: HEK293
Formulation & Reconstitution: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Target: PLA2R1
Uniprot ID: Q13018
Usage: Research use only
Molecular Characterization: PLA2R1(Glu21-Lys164) hFc(Glu99-Ala330)
Purity: The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining.
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