Background: This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. [provided by RefSeq, Feb 2011]
Description: Recombinant human PRLR Protein with C-terminal 10×His tag
Molecular Weight: The protein has a predicted molecular mass of 25.8 kDa after removal of the signal peptide. The apparent molecular mass of PRLR-His is approximately 25-35 kDa due to glycosylation.
Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Tag: C-10×His tag
Expression Host: HEK293
Formulation & Reconstitution: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.
Target: PRLR
Uniprot ID: P16471
Usage: Research use only
Molecular Characterization: PRLR(Gln25-Asp234) 10×His tag
Purity: The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining.
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