Background: The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex. [provided by RefSeq, Jul 2010]
Description: Human SMO-Strep full length protein-synthetic nanodisc
Molecular Weight: The human full length SMO-Strep protein has a MW of 86.4 kDa
Protein Families: ES Cell Differentiation/IPS ,Transmembrane,Stem cell relevant signaling - DSL/Notch pathway,Druggable Genome,
Protein Pathways: GPCRDB Other,Hedgehog Netpath 10,Hedgehog Netpath 10,Apoptosis,Cancer,Notch,
Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Tag: C-Flag&Strep Tag
Expression Host: HEK293
Formulation & Reconstitution: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments.
Target: SMO
Uniprot ID: Q99835
Usage: Research use only
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