Iberdomide (Standard), CAS 1323403-33-3

Iberdomide (Standard), CAS 1323403-33-3
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MEXHY-101291R-0
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MedChemExpress

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Product Description: Iberdomide (Standard) is the analytical standard of Iberdomide. This product is intended for research and analytical applications. Iberdomide (CC-220) is an orally active and potent cereblon (CRBN) E3 ligase modulator (CELMoD) with an IC50 of ~150 nM for cereblon-binding affinity. Iberdomide, a derivative of Thalidomide (HY-14658), has antitumor and immunostimulatory activities[1][2].

Formula: C25H27N3O5

References: [1]Chad C Bjorklund, et al. Iberdomide (CC-220) is a potent cereblon E3 ligase modulator with antitumor and immunostimulatory activities in lenalidomide- and pomalidomide-resistant multiple myeloma cells with dysregulated CRBN. Leukemia. 2020 Apr;34(4):1197-1201./[2]Erin W Meermeier, et al. Tumor burden limits bispecific antibody efficacy through T cell exhaustion averted by concurrent cytotoxic therapy. Blood Cancer Discov. 2021 Jul;2(4):354-369.

CAS Number: 1323403-33-3

Molecular Weight: 449.50

Research Area: Inflammation/Immunology; Cancer

Target: Apoptosis;Ligands for E3 Ligase;Molecular Glues;Reference Standards
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Artikelnummer MEXHY-101291R-0
Hersteller MedChemExpress
Hersteller Artikelnummer HY-101291R-0
Verpackungseinheit Get quote
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