iLite® TRL4, Assay Ready Cells

iLite® TRL4, Assay Ready Cells
Artikelnummer
WIEBM4025
Verpackungseinheit
250 µl
Hersteller
Svar Life Science / Eurodiagnostica

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Toll-like receptors (TLRs) are a family of pattern recognition receptors that induce pro-inflammatory responses to invading pathogens, such as bacteria, fungi, viruses, and parasites. TLR4, the most extensively studied TLR, is activated by lipopolysaccharide (LPS) – a common component of Gram-negative bacteria. In addition to LPS, a number of damage-associated molecular patterns (DAMPs), have also been shown to be capable of activating TLR4. Upon activation of TLR4, downstream signaling pathways are activated leading to the production of inflammatory cytokines and chemokines.
iLite TLR4 Assay Ready Cells can be used to determine the activity of both TLR4 agonist and antagonist drugs, as well as any neutralizing antibodies against such drugs – all using the same assay. It is based on a human erythroleukemic cell line that has been genetically engineered and optimized for the quantification of LPS and for the detection of TLR4 inhibiting activity by specific and proportional expression of Firefly Luciferase. A second Renilla Luciferase reporter gene can be used for normalization of cell counts and to compensate for serum matrix effects.
Mehr Informationen
Artikelnummer WIEBM4025
Hersteller Svar Life Science / Eurodiagnostica
Hersteller Artikelnummer BM4025
Verpackungseinheit 250 µl
Mengeneinheit PAK
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