Target Synonym: HHF;CD220;HHF5;INSR;IR;Insulin R;INSR;IR;Insulin Receptor
Background: This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants.
Immunogen: Recombinant Human Insulin Receptor/INSR/CD220 Protein
Buffer: 0.2 μm filtered solution in PBS
Dilution: IHC-P 1:100-1:500;
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