Ivosidenib-13C5

Product Description: Ivosidenib-13C5 (AG-120-13C5) is 13C labeled Ivosidenib. Ivosidenib (AG-120) is an orally active inhibitor of isocitrate dehydrogenase 1 mutant (mIDH1) enzyme, it exhibits profound d-2-hydroxyglutatrate (2-HG) lowering in vivo. Ivosidenib (AG-120) has the potential for AML therapy due to its acceptable safety profile and clinical activity[1].

Applications: Metabolism-sugar/lipid metabolism

Formula: C23 13C5H22ClF3N6O3

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216./[2]Popovici-Muller J, et al. Discovery of AG-120 (Ivosidenib): A First-in-Class Mutant IDH1 Inhibitor for the Treatment of IDH1Mutant Cancers. ACS Med Chem Lett. 2018 Jan 19;9(4):300-305.

Molecular Weight: 587.92

Research Area: Cancer;Metabolic Disease

Target: Isocitrate Dehydrogenase (IDH);Isotope-Labeled Compounds

• Artikelnummer: MEXHY-18767S2-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-18767S2-0
• Verpackungseinheit: Get quote
• Mengeneinheit: STK