Target Synonym: LEP;LEPD;OB;OBS;leptin;Obesity Homolog;Obese protein;Obesity factor;FLJ94114;homolog of;Leptin (murine obesity homolog);Leptin (obesity homolog;Leptin Murine Obesity Homolog;Leptin Precursor Obesity Factor;mouse;mouse);Obese;Obesity;Obesity homolog mouse;Obesity Murine Homolog Leptin;OTTHUMP00000212285
Background: Leptin is a protein product of the mouse obese gene. Mice with mutations in the obese gene that block the sythesis of Leptin have been found to be obese, diabetic and to have reduced activity, metabolism and body temperature. cDNA clones encoding Leptin have been isolated from human, simian, mouse and rat cells. Human Leptin shares approximately 84% sequence identity with the mouse protein. Human Leptin cDNA encodes a 167 amino acid residue protein with a 21 amino acid residue signal sequence that is cleaved to yield the 146 amino acid residue mature protein. The expression of Leptin mRNA has been shown to be restricted to adipose tissue.
Immunogen: Recombinant Human Leptin protein
Buffer: 0.2 μm filtered solution in PBS
Dilution: WB 1:500-1:1000;
Calculated MW: 16 kDa
Observed MW: 14 kDa
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