Product Description: LY266097 hydrochloride is a selective 5-HT2B receptor antagonist with pKis of 7.7, 9.8, and 7.6 for 5-HT2A, 5-HT2B, 5-HT2C, respectively. 5-HT2B receptor blockade contributes to the research in depression[1].
Applications: COVID-19-immunoregulation
Formula: C21H24Cl2N2O2
References: [1]Rami Hamati, et al. Serotonin-2B receptor antagonism increases the activity of dopamine and glutamate neurons in the presence of selective serotonin reuptake inhibition. Neuropsychopharmacology. 2020 Nov;45(12):2098-2105./[2]Luc Maroteaux, et al. New therapeutic opportunities for 5-HT 2 receptor ligands. Pharmacol Ther. 2017 Feb;170:14-36.
CAS Number: 172895-39-5
Molecular Weight: 407.33
Compound Purity: 99.60
Research Area: Inflammation/Immunology
Solubility: DMSO : 62.5 mg/mL (ultrasonic;warming;heat to 60°C)
Target: 5-HT Receptor
Deutsch
English
