Description: MCL0020 is a potent and selective melanocortin MC4 receptor antagonist (IC50 values are 11.63, 1115, and >10,000 nM at MC4, MC3, and MC1 receptors, respectively). It significantly reverses stress-induced anorexia without affecting food intake in free-feeding rats and exhibits anxiolytic-like activity in vivo.
CAS Number: 475498-26-1
Formula: C34H39N7O4
Molecular Weight: 609,72
References: Chaki et al (2003) Involvement of the melanocortin MC4 receptor in stress-related behavior in rodents. Eur.J.Pharmacol. 474 95 PMID: