Product Description: Methapyrilene is a histamine antagonist, a pyridine chemical with anticholinergic activity. Methapyrilene can cause target organ-specific epigenetic alterations, such as a decrease in DNA methylation levels. Methapyrilene induces hepatocellular carcinoma in rats[1][2].
Applications: Cancer-programmed cell death
Formula: C14H19N3S
References: [1]Volodymyr Tryndyak, et al. Effect of aflatoxin B1, benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells. Food Chem Toxicol. 2018 Nov;121:214-223./[2]Andrew Craig, et al. Systems toxicology: integrated genomic, proteomic and metabonomic analysis of methapyrilene induced hepatotoxicity in the rat. J Proteome Res. 2006 Jul;5(7):1586-60
CAS Number: 91-80-5
Molecular Weight: 261.39
Compound Purity: 99.66
Research Area: Cancer; Neurological Disease
Solubility: 10 mM in DMSO
Target: Histamine Receptor;mAChR
Deutsch
English
