Target: mGluR5
Conjugate: APC
Product Type: Monoclonal
Clone Number: N75/3 (Formerly sold as S75-3)
Immunogen: Fusion protein amino acids 824-1203 (cytoplasmic C-terminus) of rat mGluR5b
Swiss-Prot: P31424
Purification: Protein G Purified
Storage Buffer: 95.64mM Phosphate, 2.48mM MES and 2mM EDTA
Concentration: 1 mg/ml
Specificity: Detects ~130kDa (both mGluR1 and mGluR5).
Cellular Localization: Cell Membrane
Scientific Background: The AMPA receptor is a non-NMDA-type ionotropic transmembrane receptor for glutamate that mediates fast synaptic transmission in the CNS. AMPARs are composed of four types of subunits, designated as GluR1, GluR2, GluR3 and GluR4, which combine to form tetramers (1, 2).
References: 1. Mayer M.L. (2005) Current Opinion in Neurobio. 15(3): 282-288.2. Keinane K., et al. (1990) Science. 249: 556-560.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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