Product Description: Monatepil maleate (AJ-2615) is a potent and orally active Ca2+-channel antagonist and a noncompetitive ACAT inhibitor. Monatepil maleate decreases blood pressure and improves plasma lipid metabolism. Monatepil maleate has the potential for the research of hyperlipidemia[1][2].
Applications: Metabolism-sugar/lipid metabolism
Formula: C32H34FN3O5S
References: [1]Ikeno A, et al. Effects of monatepil maleate, a new Ca2+ channel antagonist with alpha1-adrenoceptor antagonistic activity, on cholesterol absorption and catabolism in high cholesterol diet-fed rabbits. Jpn J Pharmacol. 1998 Nov;78(3):303-12. /[2]Sumiya T, et al. Inhibitory effect of monatepil maleate on acyl-CoA:cholesterol acyltransferase activity in the liver of cholesterol-fed Japanese monkeys. Am J Hypertens. 1997 Jul;10(7 Pt 1):779-85.
CAS Number: 103379-03-9
Molecular Weight: 591.69
Research Area: Metabolic Disease; Cardiovascular Disease
Solubility: 10 mM in DMSO
Target: Acyltransferase;Calcium Channel
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