Product Description: MRS-1706 is a potent and selective adenosine A2B receptor inverse agonist. MRS-1706 has Ki values of 1.39, 112, 157, and 230 nM for human A2B, A2A, A1 and A3 receptors respectively. MRS-1706 blocks adenosine-mediated cAMP induction[1][2].
Applications: COVID-19-immunoregulation
Formula: C27H29N5O5
References: [1]Li Q, et, al. ZM241385, DPCPX, MRS1706 are inverse agonists with different relative intrinsic efficacies on constitutively active mutants of the human adenosine A2B receptor. J Pharmacol Exp Ther. 2007 Feb;320(2):637-45./[2]Mi T, et, al. Excess adenosine in murine penile erectile tissues contributes to priapism via A2B adenosine receptor signaling. J Clin Invest. 2008 Apr;118(4):1491-501.
CAS Number: 264622-53-9
Molecular Weight: 503.55
Compound Purity: 98.07
Research Area: Inflammation/Immunology
Solubility: DMSO : 240 mg/mL (ultrasonic)
Target: Adenosine Receptor
Deutsch
English
