Product Description: MZ 1 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4. MZ 1 potently and rapidly induces reversible, long-lasting, and selective removal of BRD4 over BRD2 and BRD3. Kds of 382/120, 119/115, and 307/228 nM for BRD4 BD1/2, BRD3 BD1/2, and BRD2 BD1/2, respectively[1].
Applications: Cancer-programmed cell death
Formula: C49H60ClN9O8S2
References: [1]Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521./[2]Zengerle M, et al. Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4. ACS Chem Biol. 2015 Aug 21;10(8):1770-7./[3]Otto C, et al. Targeting bromodomain-containing protein 4 (BRD4) inhibits MYC expression in colorectal cancer cells. Neoplasia. 2019 Nov;21(11):1110-1120.
CAS Number: 1797406-69-9
Molecular Weight: 1002.64
Compound Purity: 98.87
Research Area: Cancer
Solubility: DMSO : 100 mg/mL (ultrasonic)
Target: Epigenetic Reader Domain;PROTACs
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