Product Description: Naphazoline (Naphthazoline) nitrate is an α-adrenergic receptor agonist. Naphazoline nitrate reduces vascular hyperpermeability and promotes vasoconstriction. Naphazoline nitrate reduces the levels of inflammatory factors (TNF-α, IL-1β and IL-6), cytokines (IFN-γ and IL-4), IgE, GMCSF, and NGF. Naphazoline nitrate can be used for non-bacterial conjunctivitis research[1][2].
Applications: COVID-19-immunoregulation
Formula: C14H15N3O3
References: [1]Quan L, et, al. Treatment with olopatadine and naphazoline hydrochloride reduces allergic conjunctivitis in mice through alterations in inflammation, NGF and VEGF. Mol Med Rep. 2016 Apr;13(4):3319-25./[2]Yamaguchi I, et, al. Central and peripheral adrenergic mechanisms regulating gastric secretion in the rat. J Pharmacol Exp Ther. 1977 Oct;203(1):125-31.
CAS Number: 5144-52-5
Molecular Weight: 273.29
Compound Purity: 98.0
Research Area: Inflammation/Immunology; Cardiovascular Disease; Cancer
Solubility: DMSO : 100 mg/mL (ultrasonic)
Target: Adrenergic Receptor;Interleukin Related;TNF Receptor;VEGFR
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