Product Description: NCT-501 is a potent and selective theophylline-based inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1), inhibits hALDH1A1 with IC50 of 40 nM, typically shows better selectivity over other ALDH isozymes and other dehydrogenases (hALDH1B1, hALDH3A1, and hALDH2, IC50 >57 μM).
Applications: Cancer-programmed cell death
Formula: C21H32N6O3
References: [1]Kulsum S et al. Cancer stem cell mediated acquired chemoresistance in head and neck cancer can be abrogated by Aldehydedehydrogenase 1 A1 inhibition.
Mol Carcinog. 2016 Jul 6./[2]Yang SM, et al. Discovery of NCT-501, a Potent and Selective Theophylline-Based Inhibitor of Aldehyde Dehydrogenase 1A1(ALDH1A1). J Med Chem. 2015 Aug 13;58(15):5967-5978.
CAS Number: 1802088-50-1
Molecular Weight: 416.52
Compound Purity: 99.59
Research Area: Cancer
Solubility: DMSO : 3.57 mg/mL (ultrasonic;warming;heat to 60°C)
Target: Aldehyde Dehydrogenase (ALDH)
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