NLRP3, CAS 256373-96-3

NLRP3 inflammasome activation inhibitor

Product Type: Inhibitor.

CAS No.: 256373-96-3.

MolecularFormula: C20H23N2O5S ∙ Na.

Molecular Weight: 426,5.

Source: Synthetic.

Purity: >98% (HPLC); NMR (Conforms).

Solubility: May be dissolved in water (30 mg/ml): or DMSO (40 mg/ml).

Appearance: White powder.

PubChem CID: 1234617  .

Scientific Background: NLRP3 (MCC950) was originally found to act as a cytokine release inhibitory drug (CRID), arresting activated monocytes and preventing activation of caspase-1(1). Discovered to be a novel inhibitor of the NLRP3 and AIM2 inflammasomes(2). Blocks canonical and noncanonical NLRP3 activation at nanomolar concentrations3. Inhibits interleukin 1β (IL-1β) secretion in vivo and attenuates the severity of experimental autoimmune encephalomyelitis (an MS disease model)(3). Disrupts the interaction between AIM2 and ASC in a reconstituted cell-free inflammasome(4). A valuable new tool for exploring the pathophysiology of NLRP3.

References: 1. Laliberte R.E. et al. (2003) J. Biol. Chem. 278(19):16567-78. 2. Coll R.C., et al. (2011) PLoS One. 6(12):e29539. 3. Coll R.C., et al. (2015) Nat. Med. 21(3):248-255. 4. Kaneko N., et al. (2015) J. Immunol. Methods. 426:76-81.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-604-25MG
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-604-25MG
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK