Target: NPAS4
Conjugate: Biotin
Product Type: Monoclonal
Clone Number: N408/79 (Formerly sold as S408-79)
Immunogen: Fusion protein amino acids 597-802 (C-terminus) of rat Npas4.
Swiss-Prot: Q8CJH6
Purification: Protein G Purified
Storage Buffer: 136.36mM Ethanolamine, and 9.55mM Sodium Bicarbonate in 95.45% PBS
Concentration: 1 mg/ml
Specificity: Detects ~90kDa.
Cellular Localization: Cytoplasm / Nucleus
Tissue Specificity: Highly expressed in the brain, with lower expression found in endocrine tissue.
Scientific Background: NPAS4 belongs to the Per-Arnt-Sim family of neuronal specific transciption factors, all involved in the development and maintenance of learning and memory pathways (1). NPAS4 is a transcription factor that regulates the formation and maintenance of inhibitory synapses, and can activate the CNS midline enhancer element and the expression of the drebrin gene. Deregulation has been to be associated with developmental disorders such as schizophrenia and autism (2).
References: 1. Zhaohui Z., et al. (2014) Exp Ther Med. 7(4): 1045-1049.2. Coutellier L., et al. (2012) Plos One. 7(9): e46604.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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