Clone Name: HMV3970
Application Note: IHC-P: 1:100-1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Specificity/Sensitivity: <b>Highly recommended for IHC-P in human tissues.</b>
Form: Liquid
Buffer (with preservative): PBS, 2% BSA, 0.025% ProClin 300.
Concentration: 7 μg/ml (Please refer to the vial label for the specific concentration.)
Background: This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [provided by RefSeq, Apr 2014]
Uniprot ID: P46527
Antigen Species: Human
Immunogen: Recombinant fragment of human p27 Kip1
Purification: Affinity purified by Protein A.
Conjugation: Unconjugated
Full Name: cyclin dependent kinase inhibitor 1B
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