PE-conjugated Anti-NKG2D antibody(DMC287); IgG1 Chimeric mAb

Background: Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins; which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex; a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins; where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system; and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C; member 4) family member in the same cluster.

Description: PE-conjugated Anti-NKG2D antibody(DMC287); IgG1 Chimeric mAb

Storage & Shipping: Store at 2°C-8°C for 6 months

Formulation & Reconstitution: Liquid，PBS with 0.05% Proclin300, 213% BSA

Target: NKG2D

Uniprot ID: P26718

Usage: Research use only

Clone ID: DMC287

Purification: Purified from cell culture supernatant by affinity chromatography

Recommended Dilutions: Flow Cyt 1:100

• Artikelnummer: DMADMC100287P-100
• Hersteller: DIMA Biotechnology
• Hersteller Artikelnummer: DMC100287P-100
• Verpackungseinheit: 100 test
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Monoclonal
• Methode: Flow Cytometry
• Isotyp: Rabbit/Human Fc chimeric IgG1
• Wirt: Rabbit
• Konjugat: Conjugated, PE (Phycoerythrin)