CAS No.: 357166-29-1.
Molecular Formula: C20H19N5Na2O6 [7H2O].
Molecular Weight: 597,5.
Source: Synthetic.
Purity: >98% (TLC, HPLC); NMR (Conforms).
Solubility: May be dissolved in Water (100 mg/ml).
Appearance: White powder.
PubChem CID: 135564751.
Scientific Background: Pemetrexed is a folate antimetabolite that inhibits thymidylate synthase, dihydrofolate reductase and glycinamide ribonucleotide formyltransferase, three enzymes used in purine and pyrimidine synthesis. It is an antifolate cancer drug.
References: 1. McLeod H.L., et al. (2000) Clin Can Research: Clin Trials. 6(7): 2677-2684.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.