PF-03715455, CAS 1056164-52-3

Product Description: PF-03715455 is a potent inhaled p38 MAPK inhibitor. PF-03715455 shows some selectivity for p38α over p38β with respective IC50 values of 0.88 and 23 nM. PF-03715455 potently inhibits LPS-induced TNFα production in human whole blood (IC50=1.7 nM). PF-03715455 has potential for the treatment of COPD (chronic obstructive pulmonary disease)[1][2].

Applications: COVID-19-immunoregulation

Formula: C35H34ClN7O3S2

References: [1]Norman P, et al. Investigational p38 inhibitors for the treatment of chronic obstructive pulmonary disease. Expert Opin Investig Drugs. 2015 Mar;24(3):383-92./[2]Millan DS, et al. Design and synthesis of inhaled p38 inhibitors for the treatment of chronic obstructive pulmonary disease. J Med Chem. 2011 Nov 24;54(22):7797-814.

CAS Number: 1056164-52-3

Molecular Weight: 700.27

Research Area: Inflammation/Immunology

Solubility: 10 mM in DMSO

Target: p38 MAPK

• Artikelnummer: MEXHY-18862-25
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-18862-25
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK