PF-06465469, CAS 1407966-77-1

Product Description: PF-06465469 is a covalent inhibitor of ITK with an IC50 of 2 nM. PF-06465469 also inhibits BTK. PF-06465469 inhibits cell migration in response to CXCL12. PF-06465469 decreases PD-1 and LAG-3 expression. PF-06465469 can be used to study leukemia and T-cell lymphoma[1][2].

Applications: Cancer-Kinase/protease

Formula: C30H33N7O2

References: [1]Mamand S, et al. Comparison of interleukin-2-inducible kinase (ITK) inhibitors and potential for combination therapies for T-cell lymphoma. Sci Rep. 2018 Sep 21;8(1):14216./[2]Fu Z, et al. IL-2-inducible T cell kinase deficiency sustains chimeric antigen receptor T cell therapy against tumor cells. J Clin Invest. 2024 Nov 26;135(4):e178558.

CAS Number: 1407966-77-1

Molecular Weight: 523.63

Compound Purity: 99.48

Research Area: Cancer

Solubility: DMSO : 11 mg/mL (ultrasonic)

Target: Btk;CXCR;Itk;LAG-3;PD-1/PD-L1

• Artikelnummer: MEXHY-108691-50
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-108691-50
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK