Product Description: Pipamperone (Floropipamide) is a butyrophenone derivative and high-affinity antagonist of 5-HT2A receptor (pKi=8.2) and D4 receptor (pKi=8.0). Pipamperone is also a low-affinity antagonist of D2 receptor (pKi=6.7). Pipamperone affects neurotransmitter functions and exerts antipsychotic activity. Pipamperone is used in the research of mental disorders such as autism-related behavioral disorders and Alzheimer's disease[1][2][3][4].
Applications: Neuroscience-Neuromodulation
Formula: C21H30FN3O2
References: [1]Erik Buntinx, MD, et al. Selective Serotonergic Properties of Low-Dose Pipamperone May Enhance Antidepressant Effect: Preclinical Evidence./[2]Oekelen DV, et al. Different regulation of rat 5-HT(2A) and rat 5-HT(2C) receptors in NIH 3T3 cells upon exposure to 5-HT and pipamperone. Eur J Pharmacol. 2001 Aug 3;425(1):21-32. /[3]Petrosino B, et al. The treatment of autism with pipamperone: a case report. European Psychiatry, 2016, 33(S1): S549-S549. /[4]Kamp D, et al. Hypothermia in a patient with Alzheimer's disease receiving a combination therapy with risperidone and pipamperone. Ther Adv Psychopharmacol. 2016 Feb;6(1):55-7.
CAS Number: 1893-33-0
Molecular Weight: 375.48
Compound Purity: 99.89
Research Area: Neurological Disease
Solubility: 0.1 M HCl : 25 mg/mL (ultrasonic)/DMSO : 100 mg/mL (ultrasonic)
Target: 5-HT Receptor;Dopamine Receptor
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