Pomalidomide, CAS 19171-19-8

E3 Ubiquitin Ligase Inhibitor

CAS No.: 19171-19-8.

Molecular Formula: C13H11N3O4.

Molecular Weight: 273,2.

Source: Synthetic.

Purity: >98% (TLC); NMR (Conforms).

Solubility: May be dissolved in DMSO (50 mg/ml).

Appearance: Yellow powder.

PubChem CID: 134780.

Scientific Background: Pomalidomide, a derivative of thalidomide, is an inhibitor TNF-α production (1), enhances the activity of T cells and natural killer cells and enhances antibody- dependent cellular cytotoxicity. It also may inhibit tumor angiogenesis, and promote cell cycle arrest (2).

References: 1. D'Amato R., Lentzsch S, Anderson K.C. ad Rogers M.S. (2001) Seminars in Oncology. 28(6): 597-601. 2. Fujiwara Y., et al. (2018) Cancer Research. DOI: 10.1158/0008-5472.CAN-18-1781.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-581-25MG
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-581-25MG
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK